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SPINAL MUSCULAR ATROPHY(SMA) SMA - Coggle Diagram
SPINAL MUSCULAR ATROPHY(SMA)
DEFINITION
control the movement of their muscles due to a loss
of nerve cells in the spinal cord or brain stem.
A group of genetic disorders in which a person cannot
NURSING CARE PLAN
Maintain bedrest and immobilization devices such as traction
Perform and assist with full ROM exercises on all extremities
Note strength or effectiveness of cough
Administer pain medications
Assess breathing patterns by asking the patient to take deep breaths
CAUSES
Genetic from both parents
PATHOPHYSIOLOGY
Deletion or mutation of the SMN1 gene reduces intracellular
survival motor neurone protein levels causes spinal muscular atrophy
by motor neuron loss, muscle atrophy and weakness.
most likely by interfering with spliceosome assembly.
It is an autosomal recessive disease characterised
PHARMACOLOGICAL MANAGEMENT
Zolgensma
Risdiplam(Evrysdi)
Nusinersen or spinraza
CLINICAL MANIFESTATIONS
Problems eating and swallowing
Delayed gross motor skills
Breathing problems
Spontaneous tongue movement
Limited mobility
Curvature of the spine
Muscle weakness
