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Interneurons, Parafascicular nucleus (PFn) - Coggle Diagram

- - - - can spread ACh to a large area
  - - - ~50% co release GABA
      - some co-release Glu
        Vglu3
  - - - large soma
      - relatively smooth dendrites
        
        sparse long thin spines
        and filopodia
      - 3-5 primary neurites
      - extensive arbors
    - - ~500,000 axonal varicosities
        
        mostly volume transmission via ACh diffusion
      - can co-release GABA or Glu
      - modulate release of Glu from cortical/thalamic
        dopamine from nigrostriatal
        endocannabinoids from medium spiny
  - - - resting membrane potential -55 to -60mV
      - can fire spontaneously
        "autonomous pacemakers"
      - prominent hyperpolerisation-activated cyclic
        nucleotide-gated currents (HCN)
      - exhibit large, slow afterhyperpolarization
        potentials (AHP)
    - - pause firing in response to cues
        predictive of reward or aversion
        
        may be proceeded by a "burst"
        or followed by a "rebound"