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Fatty acid biosynthesis - Coggle Diagram
Fatty acid biosynthesis
Overview
Transport of acetyl-CoA from mitochondria to cytosol
Formation of malonyl-CoA
Rate limiting step
Elongation cycle
Problem
Excess acetyl-CoA in mitochondria
Enzyme for FA synthesis in cytosol
Acetyl-CoA out of mitochondria as citrate
Citrate converted to oxaloacetate
Conversion to pyruvate - returns to mitochondria
Reaction facilitates conversion of NADH to NADPH
Formation of malonyl CoA for FA synthesis
Acetyl-CoA carboxylase
Acetyl-CoA to malonyl-CoA
Biotin coenzyme
Hydrolysis of ATP
Producing carboxybiotin intermediate
Activated CO\(_2\) transferred to acetyl-CoA to form malonyl-CoA
2C to 3C molecule
Irreversible, rate limiting step of FA synthesis