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CPT, Fig1, Fig2, Fig3, Fig4 - Coggle Diagram
CPT
CSB disappear
TC dependent
Top1 depedent
SRSF1 dependent
Cul4 independent, CSA independent
TC-NER defect?
RRS down
ICL repair defect, detected by 8-POP click?
CSA recruitment?Matsunaga lab
CDDP, UV sensitivity?
CPT sensitizes cells more to CDDP and UV
However, CPT also sensitizes CSB KO cells to CDDP and UV
Unknown effect on TC stress response other than TC-NER
Top1 inhibition affects the recovery from TC stress?
Top1 needed for RRS?
Top1 needed for RRS in TC-NER deficient cells?
Top1 depletion sensitize cells to CDDP and UV?
TDP1/2 and XRCC1 depletion sensitize cells to CDDP and UV?
Fig1
Fig2
Fig3
Fig4