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RECOVERY PROCESS - REPAIR - Coggle Diagram
RECOVERY PROCESS - REPAIR
Introduction
Repair Process = replace injured tissue by fibrous tissue.
Involved: mesenchymal cells (connective tissue stem cell, fibrocytes & histiocytes), endothelial cells, macrophages, platelets and parenchymal cells of the injured organ.
Granulation Tissue Formation
( slightly granular and tissues appears in pink color )
Divided into 3 phases
Clearance
Phagocytic activity will be performed.
Macrophages clear off the necrotic tissue, debris and red blood cells.
Ingrowth of granulation tissue
Angiogenesis: forming new blood vessels.
Fibrogenesis: forming fibroblast by fibrocytes. Cicatrisation (inactive looking scars) formed as collagen fibrils grow increasingly.
Inflammation
Blood clot on injured area after trauma.
Acute inflammatory response happens, exudation including plasma, neutrophils and some monocytes in 24 hours.
Contraction of wounds
( wound starts contracting in 2-3 days, while it will reduced by 80% of its original size )
3 factors affecting mechanism
Contraction of collagen
= wound attach to each other and about to unite.
Discovery of myofibroblasts
= Myofibroblasts migration to the wound area with their active contraction decreases the size of the wound.
Dehydration
= removal of fluid by drying of wound.