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Methotrexate 1561993730-Methotrexate, ANTIARTHRITIC DRUGS AND SKELETAL…
Methotrexate
Indications
Juvenile idiopathic arthritis
Dermatomyositis
Non-Hodgkin's lymphoma
Breast cancer
Rheumatoid arthritis
Leukaemia
Mechanism action
Methotrexate polyglutamates inhibit AICAR more than methotrexate in rheumatoid arthritis
inhibition leads to accumulation of AICART ribonucleotide
Nucleotide synthesis inhibition prevents cell division
Which then inhibit adenosine indeaminase
Enzymes inhibition is responsible for nucleotide synthesis
Causing adenosine triphosphate accumulation
It converted to methotrexate polyglutamate by polyglutamate when entering tissues
Stimulating adenosine receptors leading to anti-inflammatory action
Side effects
nausea and vomiting
Mouth alcers
Drowsiness
Eyes redness
Dizziness
Lowered appetite
Swollen, tender gums
Fever and fatigue
Contraindications
Chronic liver disease
Active infectious disease
Methotrexate hypersensivity
Renal dysfunction
Bone marrow pypoplasia
Thrombocytopenia
Immunodeficiency syndrome
Leukopenia
Route and storage
Intramuscular
Intravenously
Orally
Store in dark, dry place
Protect from light and moisture
Opened vial to be stored up to 4weeks
References
https://www.arthritis.org
https://wwwedmd.com
https;//www.mediplus.com
ANTIARTHRITIC DRUGS AND SKELETAL MUSCLE RELAXANT
