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Antilipemic
Drugs - Coggle Diagram
Antilipemic
Drugs
Statins
Lovastatin. Altoprev
Indication:
- hypercholesterolemia,
- hyperlipidemia,
- hyperlipoproteinemia
Nursing Consideration
Side Effect:
- headache,
- constipation,
- hepatic failure,
- dizziness
Storage Condition:
- Avoid excessive heat (above 40 degrees C).
- Avoid excessive humidity. Store between 20 to 25 degrees C
Contraindication:
- hypersensitivity,
- active hepatic disease
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Bile Acid Resins
Cholestyramine Prevalite
Indication:
- hypercholesterolemia
- pruritus
- diarrhea
Nursing Consideration
Side Effect: osteoporosis dizziness, fatigue, wheezing, prolonged bleeding time, constipation
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Contraindication:
- complete biliary obstruction
- GI obstruction
- haemophilia
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Mechanism of Action: releases chloride and combines with bile acids in the intestine to form insoluble
Fibrates.
Fenofibrate finoglide
Indication:
- severe hypertriglyceridemia
- reduce elevated LDL-cholesterol increase
- HDL-cholesterol
Nursing Consideration
Side Effect
- abdominal pain
- headache
- fever
- constipation
- phlebitis
Storage Condition:
- Protect from light
- Protect from moisture
- Store at 25 degrees C
Contraindication:
- hypersensitivity
- renal failure
- severe renal disease
- breast-feeding women
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Mechanism of Action: induces lipoprotein lipase and decreases hepatic production of apolipoprotein CIII via PPAR activity
Monoclonal Antibodies
Alirocumab. Praluent
Indication:
- eterozygous familial hypercholesterolemia
- myocardial infarction prophylaxis
Nursing Consideration
Side Effect
- confusion
- injection site reaction
- myalgia
- musculoskeletal pain
Storage Condition:
- Do not freeze
- Protect from extreme heat Protect from light
- Refrigerate (between 2 and 8 degrees C)
- Store in original container
Contraindication:
- Hypersensitivity vasculitis
- hypersensitivity reactions
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Mechanism of Action: antibody that binds to and inhibits proprotein convertase PCSK9 binding to low-density lipoprotein receptors
Miscellaneous EZETIMIBE
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Nursing Consideration
Side Effect:
- elevated hepatic enzymes
- infection fatigue
- pancreatitis
- dizziness
Storage Condition:
- Protect from moisture
- Store at 25 degrees C
Contraindication:
- moderate or severe hepatic disease
- Breast-feeding
- premenarchal girls
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Mechanism of Action: inhibiting the absorption of cholesterol and phytosterol by the small intestine without altering the absorption of fat-soluble vitamins and nutrients
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