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Antiviral drug - Xofluza (Baloxavir Marboxil) - Coggle Diagram
Antiviral drug - Xofluza (Baloxavir Marboxil)
Machenism action
XOFLUZA is a prescription medicine used to treat the flu (influenza) in people 12 years of age and older who have had flu symptoms for no more than 48 hours
It is not known if XOFLUZA is safe and effective in children less than 12 years of age or weighing less than 88 pounds (40 kg)
Baloxavir marboxil is a prodrug that is converted by hydrolysis to baloxavir, the active form that exerts anti-influenza virus activity. Baloxavir inhibits the endonuclease activity of the polymerase acidic (PA) protein, an influenza virus-specific enzyme in the viral RNA polymerase complex required for viral gene transcription, resulting in inhibition of influenza virus replication. The 50% inhibitory concentration (IC50) values of baloxavir ranged from 1.4 to 3.1 nM (n=4) for influenza A viruses and 4.5 to 8.9 nM (n=3) for influenza B viruses in a PA endonuclease assay. Viruses with reduced susceptibility to baloxavir have amino acid substitutions in the PA protein.
Contraindications
It is not known if XOFLUZA is safe and effective in children less than 12 years of age or weighing less than 88 pounds (40 kg)
Indications
Indicated for treatment of acute uncomplicated influenza in patients aged ≥12 years who have been symptomatic for ≤48 hr and otherwise healthy, or at high risk of developing influenza-related complications
<12 years: Safety and efficacy not established.
≥12 years. <80 kg: 40 mg PO as a single dose.
Indicated for postexposure prophylaxis of influenza in patients following contact with an individual who has influenz
<80 kg: 40 mg PO as a single dose
≥80 kg: 80 mg PO as a single dose
Route of administration
Administered orally
Storage conditions
Store XOFLUZA in its blister package at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]
Side effects
Headache
Sinusitis
Nausea
Bronchitis
Diarrhea