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MALE AND FEMALE HORMONAL DRUGS CYPROTERONE ACETATE(ANTIANDROGEN) download…
MALE AND FEMALE HORMONAL DRUGS CYPROTERONE ACETATE(ANTIANDROGEN) 
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MECHANISM OF ACTION
Cyproterone acetate inhibits competitively the effect of androgens on androgen-dependent target organs. it shields the prostate from the effect of androgens originating from the gonads or the adrenal cortex. Prostatic carcinoma and its metastases are in general androgen-dependent, Androcur exerts a direct antiandrogenic action on the tumour and its metastases.
Cyproterone acetate has a progestogenic action exerting a negative feedback effect centrally on the hypothalamic receptors so leading to a reduction in gonadotropin release and to diminished production of testicular androgens. Treatment with cyproterone acetate in men results in a reduction of sexual drive and potency and inhibition of gonadal function. These changes are reversible following discontinuation of the therapy.
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SIDE EFFECTS
ARE
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breast pain, change in breast size, breast swelling and/or tenderness
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CONTRAINDICATIONS
DO NOT USE IF
Pregnancy, lactation, and breastfeeding
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Previous or existing meningioma, hyperprolactinemia, or prolactinoma
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INDICATIONS
In men androgens help cancer cells to grow in some types of prostate cancer. By blocking these hormones may slow or stop the growth of cancer. may also be used after surgical removal of testes to treat side effects such as hot flushes and to prevent any initial worsening of the disease.
in women, androgens may increase hair growth, loss of scalp hair and secretion of oil from the sweat glands. By blocking these hormones and may slow or stop excessive hairiness, loss of scalp hair, acne and oily skin.
REFERENCES
- Androcur Consumer Medicine Information. Pacific Highway Pymble, Bayer Australia Pty Ltd. March 2013.
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