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EVOLOCUMAB EVOLOCUMAB - Coggle Diagram
EVOLOCUMAB
NAME
Repatha
REFERENCES
Evolocumab-LiverTox-NCBI Bookshelf.
https://www.ncbi.nlm.nih.gov/books/NBK548469
Repatha(evolocumab) dosing, indications, interactions, adverse effects and more.
https://reference.medscape.com/drug/repatha-evolocumab-1000002
MECHANISM OF ACTION
Resulting in decreased LDL-C clearance and increased plasma LDL-C.
PCSK9 inhibitors decrease LDLR degradation by PCSK9
PCSK9 is a serine proteas that destroys LDLR in the liver
And improve LDL-C clearance and lower plasma LDL-C
LDL-C is cleared from the circulation through LDL receptor pathway
Monoclonial antibody that binds to PCSK9
SIDE EFFECTS
Dizziness
Hypertension
Headache
Nausea
Sinusitis
Muscle spasm
Urinary tract infection
Fatigue
STORAGE
Store in the original carton
Protect from direct sunlight
Refrigerator between 2-8 degrees celcius
Do not shake
Do not expose to temperatures higher than 25 degrees celcius
CONTRAINDICATION
History of serious hypersensitivity to evolocumab
Hypersensitivity to any excipients
Pregnancy or nursing mother
Over 60 years
INDICATION
Treatment for primary hyperlipidemia
Reduce high cholesterol levels
Prevention of cardiovascular events like stroke
ROUTE OF ADMINISTRATION
Subcutaneous
