ANTILIPEMIC DRUGS
Statins
Side effects
Names
Machanism of action
Contraindications
Route of administration
indicatiions
Storage
Reduces HDL levels by 2% to 15%
lowers triglyceride levels
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Reduces LDL levels by 30 to 40%
liver disease
Elevation in liver enzymes
Pregnancy ,Allergy
Lowers the rate of cholesterol production
Inhibits HMG-CoA reductase which is used by the liver to produce cholesterol
Myopathy ,Elevation in lover enzymes
Rash and headache
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Liver disease
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Fluvastatin ,Pravasttin
Simvastatin ,Atavorstatin
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Oral
keep away from children
dispose correctly
store in a cool dry place
keep away from sunlight
Fibrates
Contraindications
Route of administration
Machanism of action
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Storage conditions
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Ciprofibrate , Clofibrate
Fenofibrate
Gemfibrozil ,Bezafibrate
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Blurred vision ,Headache
Abdominal discomfort , Prolonged prothrombin time
Diarrhoea ,Nausea and Increased risk of gall stones
Activate lipase which breaks down cholesterol
Supress the release of free fatty acid from adipose tissue
inhibit production of tryglyrecides in the liver
increase secretion of cholesterol in the bile
Severe liver or kidney disease
Gall bladder disease
CIrrhoosis
Rug allergy
Oral
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Indications
Treatment type iii ,iv and v hyperlipidemias
Store in a cool dry place
keep away from children
Keep away from sunlight