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Potassium-Sparing Diuretics(amiloride)
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Potassium-Sparing Diuretics(amiloride)
Mechanism of action
Amiloride works by directly blocking the epithelial sodium channel (ENaC) with an IC50 around 0.1 μM, indicating potent blockad
Antagonism of ENaC thereby inhibits sodium reabsorption in the late distal convoluted tubules, connecting tubules, and collecting ducts in the nephron
This promotes the loss of sodium and water from the body, and reduces potassium excretion
The drug is often used in conjunction with a thiazidediuretic to counteract with a potassium-losing effect
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References
MIDAMOR Product Monograph" (PDF). AA Pharma Inc. August 25, 2010. Retrieved 7 June 2018
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Nurses consideration
Monitor liver and renal function tests to identify need for possible dose adjustment and toxic effects
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