Spironolactone
Contraindications
Brand names
Storage
Route of administration
Indications
Side effect
Mechanism of action
Keep in original container , tightly closed
Keep out of reach of children
Away from moisture and heat
Store at a room temperature
Severe and end stage kidney disease
Concomitant use of eplerenone
Hyperkaemia :
Addisons syndrome
Extreme tiredness
Extreme thirst, hyperkalemia
Allergic reactions like rash , hives
Low blood pressure
Aldosterone antagonists with diurectic and hypertensive effects
Competitive binding of receptors are aldoresteron dependant :
Na-K exchange sites in distal convulated tubules
Resulting in increased secretion of Na , CL
Reduce swelling from liver disease
And nephrotic syndrome .Sinko E, 2019
Treat high blood pressure , heart failure and hyperaldosteronism
Oral
Aldactone