Spironolactone

Contraindications

Brand names

Storage

Route of administration

Indications

Side effect

Mechanism of action

Keep in original container , tightly closed

Keep out of reach of children

Away from moisture and heat

Store at a room temperature

Severe and end stage kidney disease

Concomitant use of eplerenone

Hyperkaemia :

Addisons syndrome

Extreme tiredness

Extreme thirst, hyperkalemia

Allergic reactions like rash , hives

Low blood pressure

Aldosterone antagonists with diurectic and hypertensive effects

Competitive binding of receptors are aldoresteron dependant :

Na-K exchange sites in distal convulated tubules

Resulting in increased secretion of Na , CL

Reduce swelling from liver disease

And nephrotic syndrome .Sinko E, 2019

Treat high blood pressure , heart failure and hyperaldosteronism

Oral

Aldactone