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Thiazide diuretics( metolazone)
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Thiazide diuretics( metolazone)
Mechanism of action
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resulting in a decrease in sodium reabsorption and an increase in sodium, chloride and water excretion
The shift result in hypovolemia, keeping the peripheral vascular resistance low and returning cardiac output to normal
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References
Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 457
Braunwald E (2005). "Heart Failure and Cor Pulmonale". In Kasper DL, et al. (eds.). Harrison's Principles of Internal Medicine (15th ed.
Katague DB. "Chemistry Reviewer Still in Lab" (PDF). News Along the Pike. Food and Drug Administration' s Center for Drug Evaluation and Research