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(Thiazide and thiazide-like diuretic), (:indications), Google scholar -…
(Thiazide and thiazide-like diuretic)
Storage, condition, and route of administration
Route onset peak duration
Oral 60 minutes .60-120 min.6-8h
Ethacrynic acid is used in oral form in some situations but not in infant
IV , IM 5 min.30 min.2h
Contraindication
Liver disease could interfere with drug metabolism and lead to drug toxicity
Bipolar disorder can be exacerbated by calcium changes brought about by the use of this drug
Mechanism of action
It cause active pumping out of chloride from the cells lining the ascending limb of loop of henle and distal tubule by blocking the chloride pump, since sodium passively moves with chloride to maintain electrical neutrility , both sodium and chloride are excreted in the urine.Sinko E, 2019.
Side effect
GI : GI upset
GU: hypokalemia
CV:hypotension , arrhythmias
CNS: weakness
:indications
First- line drug for management of essential hypertension
Considered to be a milder form of diuretic compared to loop diuretics
Google scholar