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OSMOTIC DIURETICS(mannitol)
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OSMOTIC DIURETICS(mannitol)
Mechanism of action
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Mannitol, when administered intravenously, exerts its osmotic effect as a solute of relatively small molecular size being largely confined to the extracellular space
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Side effects
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fever, chills, headache, runny nose
swelling, rapid weight gain
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Nursing consideration
Assess for drug allergies, fluid and electrolyte disturbances, hepatorenal diseases, glucose tolerance abnormalities
Perform a thorough physical assessment to establish baseline data before drug therapy begins, to determine effectiveness of therapy, and to evaluate for occurrence of any adverse effects associated with drug therapy
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References
Bhardwaj A. Osmotherapy in neurocritical care, Curr Neurol Neurosci Rep, 2007, vol. 7 (pg. 513-21
Wakai A, Roberts I, Schierhout G. Mannitol for acute traumatic brain injury, Cochrane Database Syst Rev, 2007pg. CD001049
Sear JW. Kidney dysfunction in the postoperative period, Br J Anaesth, 2005, vol. 95 (pg. 20-32)