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Long-term Methamphetamine Use, Claudia Lopez NRS 426 5 May, 2021 -…
Long-term Methamphetamine Use
Vascular Damage
decreased NO sensitivity
Pulmonary Hypertension
Pulmonary Edema
respiratory distress
impaired gas exchage
Autophagy, ROS, Apoptosis
Endothelial Activation
increased permiability
increased interstitial fluid
edema
difficulty breathing
electrolyte imbalances
increased ROS
increased ICAM-1/VCAM-1
Enhanced Inflammation
increased T cells
increased ROS
increased IL-1B, IL-6, IFNy
Mitochondrial dysfunction
decreased ATP
increased intracellular calcium
increased contractility
cardiac hypertrophy
decreased cardiac function
Remodeling
Structural
Fibrosis
infflamation
Cardiac Arythmia
Electrical
L-type
Cardiac Arythmias
Ca+ channels
K channels
Sympathetic Activation
Prolonged QT
Excess Catecholamine Levels
increased inflammation
increased fibrosis
dilated cardiomyopathy
cardiac dysfunction
mitochondrial dysfunction
myocyte necrosis
ischemia
Claudia Lopez
NRS 426
5 May, 2021