Extreme hyperglycaemia--severe osmotic diuresis--fluid volume deficient---( sodium, potassium, phosphorus) electrolytes imbalance----profound dehydration----hyperosmolality----hypovolemia---which will result to renal perfusion, hypotension, haemoconcentration, oliguria, tissue anoxia, hyperviscosity, anuria, lactic acid, thrombosis and seizures com and death may follow.