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Cardiac Amyloidosis, Mohty, D., Damy, T., Cosnay, P., Echahidi, N., Casset…
Cardiac Amyloidosis
Amyloidosis
deposits of insoluble fibrillary proteins
Can be localized or systemic
Precursors which can affect the heart
Light chain immunoglobulin
Mutant hereditary transthyretin
Serum Amyloid A
Secondary
Results of other illnesses
Arthritis
Crohn's disease
Treatments
Conventional Chemotherapy
Stem cell transplantation
Use of novel agents
Bortezomib
Cardiac supportive treatment
Monitoring of heart rate
Fluid and salt intakes
Usually ineffecive
Bradycardiac effects
Hypotensive effects
Diagnosis
Histological findings
Use of light microscopic examination
Biopsy of fat or salivary glands
If critical, biopsy of affected organ
Use of electron microscope
Accurate confirmation of amyloid proteins
Cardiac Involvement increases as wall thickens
Use of lambda LC isotype
RESEARCH!
Tools
Use of Cardiac biomarkers
Troponin
Prognostic tools
Electrocardiography
Echocardiography
Useful for patients with cardiac involvement
Cardiac MRI
Better characterization of abnormalities
Functional
Myocardial involvement
Depositions in spatial resolution
Mohty, D., Damy, T., Cosnay, P., Echahidi, N., Casset-Senon, D.,
Virot, P., and Jaccard, A. Cardiac amyloidosis: Updates in diagnosis
and management. Archives of Cardiovascular Diseases 106, 10 (2013), 528–
540.