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Transfusion - Coggle Diagram
Transfusion
Haemolytic transfusion reactions (HTR)
Acute
Defined as
Fever + other signs of haemolysis within 24hrs of transfusion
Confirmed by 1 or more of
Fall in H
Rise in LDH (lactate dehydrogenase enzyme)
Positive DAT
Positive cross match
Delayed
Defined as
Fever + other signs of haemolysis more than 24hrs after transfusion
Confirmed by 1 or more of
Fall in Hb
Rise in bilirubin
Positive DAT
Positive crossmatch not detectable pre-transfusion
Alloimmunisation
Development of an Ab without evidence of haemolysis
Transfusion transmissible infections (TTI)
Definition
Recipient has evidence of an infection following blood transfusion
No evidence of infection prior to transfusion
Component was donated by a donor who
Had evidence of the same transmissible infection
Is shown to contain the agent of infection
NHSBT - Blood donation testing
All donations
Blood group serology
ABO Rh K type
Antibody screen
High titre Anti-A and ANti-B screen
Microbiology
Antibodies
HIV 1+2
HBV
HCV
Syphilis
HTLV 1+2 (new donors then selective)
Nucleic acids
HCV
HIV
HBV
Hep E
Bacterial screening on all platelets
Selected donations
Blood group serology
Additional Ag phenotype
Paediatric Ab screen
Microbiology
Antibodies
CMV
T-Cruzi
Nucleic acids
West Nile Virus
other discretionary tests
HbS
Malaria