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Noninvasive diagnosis of Cardiac Amyloidosis, Rahman, J., Helou, E.,…
Noninvasive diagnosis of Cardiac Amyloidosis
Depositions in myocardial tissues
Results to a reduced ventricular compliance
Affects relaxation
Leads to contraction
Can affect myocardial vessels
Lead to local ischemia
Early recognition or detection
Necessary to improve life expectancy
Difficult to diagnose
Similarities with other cardiomyopathies
Methods
Study of patients
Performed Echocardiograph and Electrocardiograph (ECG) analysis on 198 patients
Ground truth labels were achieved through biopsy
Diagnostic tools
Echocardiographs
Results pertaining to amyloidosis presence
Thickened ventricular walls
Atrial dilation
Granular myocardial
Dysfunctions in diastolic to systolic
Electrocardiographs
results related to amyloidosis
Low-voltage
Pseudo-infarction
Endomyocardial biopsy
Hematoxylin-eosin preparation
Congo red staining
Immunohistochemical staining
Biopsy and survival results
Total of 58 patients with cardiac amyloidosis
Patients with amyloidosis were older and mostly male
More advanced heart failure than patients with no cardiac amyloidosis
ECG results
Pseudo infarction
Low-voltage
Echocardiographs
Wall thickness are larger
Left ventricular systolic and diastolic diamaters
Smaller than other patients
Sparkly/granular appearance
Conclusions
Combination of noninvasive parameters
Low voltage
Septal thickness
Increased echogenicity plus septal thickness reached 100% specificity
67% sensitivity
Rahman, J., Helou, E., Gelzer-Bell, R., Thompson, R., Kuo, C.,
Rodriguez, E., Hare, J., Baughman, K., and Kasper, E. Noninvasive
diagnosis of biopsy-proven cardiac amyloidosis. Journal of the American
College of Cardiology 43 (02 2004), 410–5.