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U13-Innate Immunity: Nonspecific Defenses of the Host, 防禦, 發燒, 異常, 下視丘,…

- - - - Redness, Swelling (edema). Heat, Pain
    - - Acute : usually good
      - Chronic : usually harmful
    - - Increase concentration in blood
      - activated (complement, cytokine, and kinins)
      - Produced by liver
      - Vasodilation(histamine, kinins, prostaglandins,and leukotrienes)
    - - limit the spread of infection to surrounding tissues
      - Repair or replace damaged tissues
      - disinfect and clean infected tissues
- - - - Antigen-antibody reaction <---- classical (古典)
      - Proteins C3, B, D, P and a pathogen  alternative(替代)
      - Mannose-binding lectin (MBL)  lectin (凝集素)
    - - Cytolysis
      - Inflammation
      - Phagocytosis
- - - - Microglial cells (nervous system)
      - Alveolar macrophages (lung)
      - Kupffer’s cells (liver)
      - Splenic macrophage (spleen)
    - - mononuclear phagocytic system
      - (reticuloendothelial) 網狀內皮