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bisphosphanates(alendronate), ibandronate, risendronate, zoledronic acid,…
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denosumab
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mechanism of action
binds RANLK,preventing RANKL from activating its receptor on osteoclast surface ,with reduced RANK-RANKLbinding ,osteoclast formation,fujnction and survival are inhibited,bone absorbtion decreases and bone mass increases.
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teriperatide
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contraindications
restricted for women and men with severe osteoporosis ,high risk of fracture
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raloxifene
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mechanism of action
binds to ostrogen receptors ,resulting in differential expression of multiple ostrogen regulated genes in different tissues. produces ostrogen like effects on bone ,reducing resorption of bone and increasing bone mineral density in posrmenopausal women thus slowing the rate of bone loss,
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