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The human connectome: a complex network - Coggle Diagram

- - - - Second, it is important to underline that the connectome is a description of brain connectivity.
      - The term description implies compression of raw data with the goal of extracting maximal information.
      - To use an analogy, an architectural description of a physical structure summarizes the major features of the design, but it does not offer a list of the dimensions and positions of all the building blocks.
      - In the case of the brain, it is not necessary to demand that the connectome be an exact replica of the connectional anatomy down to the finest ramifications of neurites and individual synaptic boutons.
      - Instead, the connectome should aim at a description of brain architecture that ranges over multiple levels of organization, reflecting the multiscale nature of brain connectivity.
      - This program may include the microscale of cells and synapses, but it does not imply that all structural connectivity must be reduced to this level.
      - Like any good road map, the human connectome should provide amultiscale description of the topological and spatial layout of connectional anatomy.
      - Such a description will require the development of sophisticated neuroinformatics methods and tools to represent information about connectivity across multiple spatial scales, for example, in the form of digital brain atlases.16
- - - - Imaging of neurons expressing fluorescent markers in a column of rat primary somatosensory cortex has provided detailed information on the number and spatial distribution of neuronal cell bodies and the pattern of thalamic afferents.29