Glipizide is a 2.5 mg to 10 mg tablet, taken as a single dose or in two divided doses, 30 minutes before breakfast. Glimepiride is available as a 1 mg, 2 mg, or 4 mg tablets, taken once a day with breakfast or twice a day with meals. For patients at increased risk for hypoglycemia, such as older patients or those with chronic kidney disease, the initial dose could be as low as 0.5 mg daily. Glyburide is available as a 1.25 mg, 2.5 mg, or 5 mg tablets, taken as a single dose or in two divided doses.
