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Cyclin B (CCNB1) - Coggle Diagram
Cyclin B (CCNB1)
Location:
In humans, it's located on chromosome #5.
In house mouse, it's located on chromosome #13.
In zebrafish, it's located on chromosome #5
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Normal gene
Functions:
it scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint. source
Cyclin B1-Cdk1 facilitates MAD1, a protein that plays a role in the spindle assembly checkpoint, release from the nuclear pore to ensure a robust spindle checkpoint. source
highly expressed in pituitary adenomas and is associated with invasiveness, suggesting that the CCNB1 gene plays an important role in the genesis and development of pituitary adenomas which are noncancerous tumors in the pituitary gland that don't spread beyond the skull. source
a regulatory protein that is involved in the regulation of the cell cycle during G2/M transition. This protein allostericlly activate the maturation-promoting factor or mitosis-promoting factor (MPF) kinase. Down-regulation of CCNB1 at protein and mRNA levels during that stage of the cell cycle can decrease cell proliferation source
Cdk1-cyclin B1 complex is also important for multiple processes during mitosis, including chromosome condensation, nuclear envelope breakdown, centrosome separation, regulation of spindle microtubule dynamics, and metaphase to anaphase transition. Source
since when its concentration is increased in a cell, the cell can enter the M phase prematurely, it'd be considered a proto-oncogene protein.
Mutant gene
There are many different types of mutations that have been observed for this gene in many samples. source. Some of them are:
missense substitution
mostly carcinoma or malignant melanoma. Source
synonymous substitution
mostly carcinoma and meningioma. Source
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there are many types of cancer that have these mutations. Most commonly: prostate, breast, lung, pancreatic, liver, and ovarian cancers.
there are other kinds of mutations like frameshift insertion, inframe deletion, frameshift deletion and other. source
Most of there mutations are gain-of-function mutations since they promote the cells to enter mitosis, leading to tumors.
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hypothetical drug
any drug that would targets Cyclin B would aim at inhibiting its abnormal function of promoting the cells to enter mitosis. And this could happen by either:
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or by targeting the cdk1/cyclin B1 complex, leading to an inhibition of the role it plays in transitining the cells from G2 phase to mitosis
these drugs/inhibitors could be either competitive inhibitors, non-competitive inhibitors, or uncompetitive inhibitors
previous research showed that knocking down cyclin B sensitizes breast cancer cells to taxol, which is a chemotherapy drug. source
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