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AQUATIC ORGANISM main-qimg-85f4ddef8132484b568223dfbf315621 - Coggle…
AQUATIC ORGANISM
Metabolite from Ziconotide
Bioactivities
Chronic pain
Method of extraction
Method of processing
:
(i) Sequentially peptide resin A and cracking to obtain a ziconotide linear peptide.
(ii) Carrying out liquid-phase one step oxidization, which has the advantages of mild conditions, simplified operation, easy after-treatment and environment friendliness, to obtain the ziconotide.
(iii) The method is beneficial to industrial large-scale production.
Specific solvent
: Trifluoracetic acid
Extracted from cone snail
Application
(i) Applied as blocking the nerves in the spinal cord that send pains signals.
(ii) It decreases ongoing caused by cancer, AIDS, failed back surgery, multiple sclerosis and neurophathy.
Class of compound
Peptide
Metabolite from Vidarabine
Bioactivities
Antiviral
Class of compound
Nucleoside
Method of extraction
Specific solvents
: Triethyl phosphate
Method of processing
:
(i) Dissolving vidarabine as a raw material in triethyl phosphate, adding phosphorus oxycloride for low-temperature reaction through protection and carrying out posttreatment, such as decoloring with active carbon and the like, to obtain a crude product of the vidarabine monophosphate.
(ii) The invention has the advantages of short process route, higher yield and reduced reaction cost.
(iii) Prepared with the method which is simple in operation, thus the industrialized production is easy to realize and the production efficiency is increased.
Application
Applied as an antiviral drug for tropical treatment of epithelial keratitis. Vidarabine used to treat Herpes simplex virus.
Extracted from sponge
Metabolite from Trabectedin
Extracted from tunicate
Bioactivities
Cancer
Class of compound
Alkaloid
Method of extraction
Specific solvents
: Hydrophilic interaction liquid chromatography and tandem mass spectrometry
Method of processing
:
(ii) Hydrolyzing the chiral acid salt obtained in step 2 with a base to obtain an optical compound III.
(i) Filtering under reduced pressure and leaching the solid with an organic solvent to obtain a chiral acid salt of a compound III.
Application
(i) Used to treat liposarcoma (a cancer that begins in smooth muscle tissue).
(ii) It works by slowing or stopping the growth of cancer cells in body
