Routes of drugs administration
Definition
It is the path by which a drug, fluid, poison or other substance is taken into the body.They are classified by the location at which the substance is applied.
Routes of drug administration
Sublingual
Rectal
Topical
Parenteral [intravenous, intramuscular and subcutaneous]
Oral
Factors that affect absorption & distribution of drugs in the body
Route of administration [IV meds absorb faster than PO meds]
Blood flow and supply
pain and stress
GI mortality
Exercise
Food or other drugs
PH
Consequences of metabolism & excretion on drugs efficacy and duration
Enzimitically mediated alteration of drug structure
metabolism of a drug decreases its therapeutic effect
it decreases the duration and intensity of drug action
majority of drugs are metabolized to increase their water solubility to allow elimination
Genetically variations in drug response
Toxic metabolites