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Propylthiouracil (PTU) - Coggle Diagram
Propylthiouracil (PTU)
Mechanism of Action
Interferes with synthesis of T3, T4; conversion of T4 to T3 the active form, is inhibited
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Administration Alerts
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Watch for weight gain, decreased anxiety, less insomnia, decreased pulse rate
Black Box Warning
SEVERE LIVER INJURY ACUTE HEPATIC FAILURE; USE AFTER METHIMAZOLE HAS BEEN TREID; USE AFTER DECISION MAD THAT RADIOACTIVE IODINE/SURGERY IS NOT VIABLE
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Drug-Drug
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Thyroid hormone; amiaderone, potassium iodide: all anatagonise effect of PTU
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Treatment Overdose
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OD= bradycardia, give atropine