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Hypoadrenocorticism - Coggle Diagram
Hypoadrenocorticism
Secondary
adrenocortical insufficiency (rare)
Iatrogenic
Glucocorticoid administration produces adrenal cortical atrophy.
gradually decrease glucocorticoid dosages over weeks to months.
Glucocorticoid/cortisol deficiency only
Spontaneous:
Pituitary failure to release ACTH or CRF
(<5% of cases?)
CS
Lethargy
depression
anorexia
vomiting,
weight loss
Vague GI sign
:forbidden: mineralocorticoid deficiency
“Atypical Addison’s”
Laboratory Findings
Hemogram
Mild non-regenerative anemia is present in 33% may be masked initially by hemoconcentration
Eosinophilia - 13%
Lymphocytosis - 9%
Normal WBC in a stressed animal!!
opposite of a stress leukogram!
Electrolyte Profile
hyponatremia
Hypochloremia
Hyperkalemia
Hypercalcemia
Na:K Ratio
(< 27:1)Hyponatremia
Most dogs with Addison’s have < 20:1 Na/K
Treatment and maintenance
Daily glucocorticoids if pituitary in origin.
monitored carefully for Na/K changes over time
may be primary but disguised by normal e- values
Most cases do NOT progress to aldosterone deficient
Primary
adrenocortical insufficiency (Addison's)