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Increased Intracranial Pressure, FIRE TEAM - Coggle Diagram

- - - - CSF Lab Values
        
        lymphocytic pleocytosis
        
        protein elevation is moderate
        
        normal glucose levels
    - - Acute
        
        Causes vary by age group
        
        infant
        
        e. coli
        
        strep pneumonia
        
        listeria monocytogenes
        
        group b streptococci
        
        young adult
        
        older adult
        
        children
        
        H. influenza
        
        neisseria meningitidis
      - Chronic
        
        typically caused by myobacterium tuberculosis
      - CSF Lab Values
        
        purulent CSF
        
        High neutrophil count (90,000)
        
        increased protein concentration
        
        LOW glucose
- - - - 80% of adult brain tumors
      - causes seizures, headaches, and focal neurologic symptoms
      - WHO Grading scale for severitity, prognosis and cellular make-up
        
        II/III
        
        anaplastic astrocytoma
        
        mutated TP53 or ATRX
        
        5-15 years
        
        anaplastic oligodendroglioma
        
        mutated 1p/19q co deletion
        
        low grade tumor - typically have the IDH1 or IDH2 mutation as well
        
        IV
        
        Gliobastoma
        
        IDH -wt
        
        mutation PTEN, pTERT, EGFR
        
        IDH- mut
        
        mutation TP53 and ATRX (like astrocytoma!)