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Immobilization Methods - Coggle Diagram

- - - - Reactive groups on the surface of BRE and solid substrate
        react to form a stable covalent bond, bonding them together
      - Elaborations
        
        • A stable covalent bond can then be formed between the BRE and the changed reactive group.
        
        • This means that the reactive groups on the substrate is change to more suitable
        
        If the substrate does not have the suitable reactive groups for reaction the substrate surface can be activate using multifunctional reagents like carbodiimide and glutaraldehyde
      - Self assembled monolayer (SAM) the ordered molecular aggregates that form
        a monolayer of material on a surface
        
        elaborations
        
        Alkyl thiols with easily modified functional groups and can self assemble on gold substrate
        
        • Hydrophobic and hydrophilic interactions drive the formation of a single layer of molecules on substrate
        
        • Highly ordered, stable and reproducible.