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Hyperadrenocorticism - Coggle Diagram
Hyperadrenocorticism
complications
increased RAAS activity = hypertension
ypercoagulability = thromboembolism
immunosuppression = infections
hyperlipidemmia
pancreatitis
gallbaldder mucocele
insulin resistance = DKA risk in diabetics
hypercalciuria = potential urolithiasis??
:cat:
most cases iatrogenic from exogenous steroids
rare endogenous
diabetes mellitus most common complaint
alopecia and
fragile skin
disorder of the hypothalamic-pituitary-adrenal axis
results in excessive cortisol
iatrogenic
"Cushing's Syndrome"
impersonators
diabetes mellitus
familial hyperlipidemia
phenobarbitol therpay
causes
pituitary-dependent HA
microadenomas (most common)
macroadenomas (>1 cm) (rare)
PDH = "Cushing's disease"
represents 80-85% of cases
adrenal-deoendent HA
more common in large breeds
50% carcinomas/50% adenomas
loss of concentrating ability
secondary intereference/disease
hyperadrenocorticism
polyphagia 50% of cases
obesity in 50% of cases
40-75% presenting with alopecia
thin skin
comedones
hyperpigmentation
pyoderms
calcinosis cutis
50-70% abdominal distention
weak mesucles
pot belly
hepatomegaly (cortisol leads to glycogen accumulation)
visceral adiposity
excessive panting
lethargy
facial nerve paralysis
:forbidden:, back to square 1
inappetance
vomiting
diarrhea
pain
icterus
clinical pathology
CBC/Chem
steroid leukogram
:arrow_down:
lymphopenia
eosinopenia
:arrow_up:
monocytosis
neutrophilia
:arrow_up:
thrombocytosis
mild hyperglycemia
increased gluconeogenesis
insulin antagonism
hyperlipidemia
cholestrol
triglycerides
UA
dilute urine
85% of cases
USG <1.020
proteinuria
UPC often >2
no hypoalbuminemia
no sediment
loss of concentrating ability present in 80-95% of cases
