Contraindication: Exfoliative dermatitis, serious rash, Intrauterine fetal death, pregnancy, Anemia, bone marrow suppression, herpes infection, immunosuppression, infection, neutropenia, requires an experienced clinician, thrombocytopenia, varicella, viral infection, Acquired immunodeficiency syndrome (AIDS), Diabetes mellitus, hypoalbuminemia, pulmonary disease, pulmonary fibrosis, pulmonary toxicity, Breast-feeding, Geriatric