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mTOR inhibitors - Coggle Diagram

- - - - storage
        
        25 degrees celcius
        
        contraindication
        
        contraindicated to patients with these conditions
        
        pneumonia caused by pneumocystis jiroveciii
        
        fluid retention
        
        disease caused by cytomegalovirus infection
        
        kidney disease
        
        malignant tumor
        
        liver problems
        
        high cholesterol
        
        route
        
        administered orally
        
        side effect
        
        changes in skin
        
        accumulation of pus
        
        black tarry stool
        
        abdominal pain
    - - sirolimus inhibit T lymphocytes activation and proliferation that occur in response to antigenic and cytokine, stimulating by mechanism that distinct of other immunosuppressants. Sirolimus also inhibit antibody production. In cell, sirolimus bind immunophilins, fk binding protein -12 to degenerate an immunosuppressive complex. this complex binds to and inhibit the activation of mammalian targets of rapamycin [mTOR]
    - - prophylaxis of renal transplant rejection
      - lymphanglolelomymatosis