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Coeliac Disease - Coggle Diagram
Coeliac Disease
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Pathophysiology
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rate of enterocyte migration massively increased but insufficient to compensate for increased cell loss from villous tips
villi become progressively shorter then absent, leaving flat mucosa behind
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Diagnosis
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strongly suggested by +ve serology + catchup growth upon gluten withdrawal (neither are dx tests, neither replace bx)
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Management
all products containing wheat, rye + barely removed
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gluten challenge
done in children when bx/gluten withdrawal results uncertain, or when disease presented before 2y/o
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serology should be -ve beforehand, +ve test if serology becomes +ve (repeat bx not needed)
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