METHOREXATE 
Mechanism of action
Adenosine binds to cell surface receptors
And suppresses many inflammatory and immune reactions
Leading into intracellular accumulation of AICAR and increased adenosine release
Polyglutamates inhibit aminoimidazole-4-carboxamide ribonucleotides transformylase
Indications
Rheumatoid arthritis
Juvenile rheumatoid arthritis
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Contraindications
Bad infection
Dehydration
Low blood counts due to bone marrow failure
Anemia
Decreased blood platelets
Condition resulting from a defective immune system
Low levels of white blood cells
Side effects
Dizziness
Drowsiness
Headache
Swollen, tender gums
Decreased appetite
redened eyes
Hairloss
Route
Subcutaneous, intramuscular
Storage
Room temperature away from sunlight
Store it in a dark, dry place