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2.3: Fever and Cough, Older male, 26 pack year history of smoking, 3 yr Hx…

- - - - Pathogen enters LRT - either from direct transmission, or autoinoculation
        
        PAMPs detected by PRRs on alveolar macrophages
        
        Macrophage lysosomes break down S. Pneumoniae, migration to lymph nodes, antigens presented on MHCII
        
        Macrophages release cytokines and PGE2
        
        IL-6, TGF-b, IL-1b, IL-23 --> activation of Th17 cells
        
        Th17 cells move to alveolar tissue and release IL-17 and IL-22
        
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        Liver produces fibrinogen, complement proteins
        
        Fibrinogen is converted to fibrin
        
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        Pyrogenic cytokines released
        
        IL-1 & TNF released into bloodstream
        
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        Increased vascular permeability and vasodilation
        
        Oedema
        
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        Vascular congestion
- - - - Mucus and particulate matter are expelled