Factors limiting stem cell treatments
iPSC-CM repair of cardiac ischaemic event
Tissue rejection
Age-related degeneration
Ethical consideration with ESCs
Poor retention of iPSCs
Arrhythmia
iPSCs-CMs lack ultrastructure and T-tubule present in natural MCs
Slower calcium signalling and lower force profiles
fibrin scaffold patch
iPSCs derived cardiomyocytes
iPSCs derived endothelial cells
iPSCs derived smooth muscles
fibrin scaffold as support
Cells within patch beat synchronously without arrhythmia in porcine model.
still poor retention
platelet production for genetic defects
thalassaemia
immunodeficiency
megakaryocyte dysfunction
iPSCs-megakaryocyte release less platelets than native megakaryocytes
iPSCs-megakaryocytes have reduced ability to generate a demarcation membrane than native megakaryocytes.
demarcation membrane is a surface invagination acting as a reservoir for production of platelets
Teratogenic property
iPSCs have lower pluripotency
CAR T-cell therapy against cancer
Platelets with new functions
reduce angiogenesis of tumours
liver repair