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(Purine analogues) .Azathioprine - Coggle Diagram
(Purine analogues)
.Azathioprine
Mechanism of action
Protein inhibitors of DNA synthesis
Owing to their direct inhibitor effect on ribonucleotide reductase
Inhibition of purine synthesis
Indications
Used in treating acute leukemias
Used in transplantation to control rejection reactions
Used as the immunosuppressive cytotoxic substance
Remission in acute granulocytic leukemias
Contraindications
It is contraindicated to a patient with stomatitis
Contraindicated to a patient with rash
Side effects
Vomiting
Nausea
Hepatitis
Pancreatitis
Storage conditions
Refrigerated at two to eight degrees Celsius
Stored under room temperature
Route of administration
Orally
Intravenously
Intramascularly