antineoplastic( campothecins)
names
topotecan
belotecan
irinotecan
trastuzumab deruxtecan
mechanism of action
They inhibit cancer cell growth by inhibiting topoisomerase I, an enzyme concerned with DNA replication
indication
metastatic colorectal cancer
metastatic ovarian cancer
side effect
diarrhea
runny nose
increased salivation
watery eyes
abdominal cramping
contraindications
route of administration
intravenous infusion
storage conditions
Storage Temperature 2-8 °C
known hypersensitivity to the drug
patients with history of severe liver disease
intestinal obstruction and long-lasting intestinal inflammation