antineoplastic( campothecins)
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names

topotecan

belotecan

irinotecan

trastuzumab deruxtecan

mechanism of action

They inhibit cancer cell growth by inhibiting topoisomerase I, an enzyme concerned with DNA replication

indication

metastatic colorectal cancer

metastatic ovarian cancer

side effect

diarrhea

runny nose

increased salivation

watery eyes

abdominal cramping

contraindications

route of administration

intravenous infusion

storage conditions

Storage Temperature 2-8 °C

known hypersensitivity to the drug

patients with history of severe liver disease

intestinal obstruction and long-lasting intestinal inflammation