Please enable JavaScript.
Coggle requires JavaScript to display documents.
Regulatory: Acute Kidney Injury (AKI) - Coggle Diagram
Regulatory: Acute Kidney Injury (AKI)
Pathophysiology/Etiology
Etiology: Fluid volume depletion leading to renal hypoperfusion
Trauma or illness causes systemic hypotension, vasodilation and decreased renal perfusion (onset)
Pressure gradient necessary to filter fluids and maintain GFR unable to occur. Accumulation of nitrogenous wastes, retention of fluid and sodium to promote fluid balance (oliguric).
Lack of blood flow damages microvascular endothelial cells, smooth muscle. Also causes tubular obstruction and injury. Cell death and necrosis in the kidney occurs.
Pro-inflammatory cytokines are released in response to cell injury, leukocytes and macrophages drawn to the kidneys.
With blood flow restoration, gradual return of UO and stabilization of Cr, BUN, and electrolytes (diuretic phase). Over time kidneys kidneys are able to regenerate endothelial cells and repair microvascular damage to restore GFR (recovery).
Prolonged fluid restoration leads to sustained cell destruction and permanently decreased renal function. Microvascular atrophy, tubule loss, and fibroblast deposits. Can lead to CKD.
Symptoms
Dizziness, lightheaded, orthostatic hypotension
Dry skin & mucous membranes
Decreased UO
Edema, swelling
SOB
AMS -- Confusion
Nausea
Tachycardia, irregular HR
Labs/Diagnostics
Blood test measuring Creatinine & BUN
Cr increased >0.3 mg/dL from baseline
High ratio, 20:1
Urine specific gravity >1.020
UO <0.5 mL/kg per hr
Reduced Na excretion <20 mEq/L
Reduced GFR
Risk Factors
HTN
Diabetes
CKD
Sepsis, hypovolemia
Complications
Hyperkalemia, cardiac disturbances
Acid-base changes, metabolic acidosis
Fluid volume overload, pulmonary edema
Collaborative Treatment
Careful fluid resuscitation to increase circulating volume & restore renal perfusion
Monitor UO and fluid overload
Address underlying cause interfering with renal perfusion
Pharmacological
Vasopressors (Norepinephrine) - increase BP to restore GFR
Inotropes (Dobutamine) - improve heart contractility
Balance electrolytes - polystyrene sulfonate, calcium infusion
Dialysis to remove waste from blood
Monitor electrolytes, especially potassium & calcium