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acute lymphoblastic leukaemia - Coggle Diagram
acute lymphoblastic leukaemia
definition; B-cell lymphoblast proliferation
epidemiology
aetiology; fusion gene of t(12:21) leads to excessive proliferation of lymphoblasts that accumulate in the bone marrow
symptoms
recurrent chest infections
bone pain
weight loss
loss of appetite and fatigue
bruising
risk factors; children
previous chemotherapy
radiation exposure
children <6 yrs
Family history;
investigations
Blood flim: lymphoblasts
bone marrow aspiration: >20% lymphoblasts
FBC;lymphocytosis, normocytic anaemia, thrombocytopaenia and low reticulocyte count
cytogenic abnormality; t(12:21), t(9:22)
clinical signs
anaemia
thrombocytopenia
bone marrow failure
lymphadenopathy
pallor, hepatosplenomegaly
testicular swelling
management