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Hershel Greene - Coggle Diagram
Hershel Greene
Lab findings
5HT-Release Assay +
4T score 7
decreased Hgb
decreased Hct
decreased platelets
D-dimer test -
PF4-heparin ELISA +
EKG w/ sinus tachycardia
negative CXR
Vitals/PE
Purpura on Arms/Legs
Hypotensive
Hypoxic
Tachycardia
Symptoms
Difficulty breathing
chest pain
Anxiety
DDx
Specific for
Heparin- Induced Thrombocytopenia
MOA
Heparin forms a complex with PF4
patient develop Ab (igG) against the complex
Platelets destroyed (thrombocytopenia)
Leads to
Increased Risk of Thrombosis
Treatment
Thrombin inhibitor
Inhibits
Thrombin
Converts Fibrinogen to
fibrin
1 more item...
Generated by
Common Pathway
2 more items...
Converted from
Prothrombin
Activates Factor 13
Crosslinks
1 more item...
Natural example
Antithrombin
Platelet Transfusion
Discontinue heparin
Pulmonary Embolism / Deep Vein Thrombosis
Myocardial Infarction