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Alkylating agents - Coggle Diagram
Chlorambucil
Mechanism of action
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Enduces cellular apoptosis via accumulation of cytosolic and
Subsequent activation of Bax, an apoptosis promoter
Contraindications
Should not be prescribed to patients, who shows
resistance to the agent.
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Side effects
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Unusual bleeding of the rectum, vagina, nose and mouth
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Bulsalfan
Mechanism of action
Forms DNA -DNA intrastand cross-linkins between DNA bases guanine and adenine and between guanine and guanine. DNA cross-links cannot be repaired by cellular machine so cell undergoes apoptosis.
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