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chest discomfort, Ischemic Heart Disease, GERD(Reflux esophagitis), acute…
chest discomfort
cardiac
心肌耗氧供氧不平衡,耗氧上升供氧下降
myocardia ischemia(包括unstable angina、non ST segment elevation MI、ST segment elevated MI)
Rule-out
:serial troponin testing, high-sensitivity troponin assays正常
Clinical presentation
:retrosternal, tightness, pressure,
輻射到脖子、下巴、肩膀、手;
服用NTG可緩解、運動加劇。
Examination
:ECG(ST elevation, Hyperacute T wave, QS pattern with ST elevation, T wave inversion)、
心肌酵素上升(CK, CK-MB, Troponin I)
感染、異常免疫反應、鄰近器官疾病-發炎
pericarditis
Clinical presentation
:pleuritic pain
relieved by bending forward
PE
:friction rub
Examination
:ECG(PR depression, ST elevation)、心包膜積水(CXR、心臟超音波)
情緒、壓力-兒茶酚胺-心臟毒性
Takotsubo cardiomyopathy
Examination:
心導管、左心室攝影、
ECG(ST-segment elevation)、心肌酵素上升
排除AMI可能
多因病毒感染
acute myocarditis
History taking
:發病前GI、呼吸道感染
Examination
:血液檢查(WBC, RBC,心肌酵素)ECG, CXR, echocardiography, coronary angiography, endomyocardial biopsy、病毒學檢查(+)
Rule-out
:心臟磁共振成像CMRI正常
心臟功能異常,以至於無法輸出足夠的血量來滿足身體組織代謝之需求。
多病因,ex:MI、高血壓、心肌、瓣膜等問題
congestive heart failure
Clinical presentaion
:dyspnea, orthopnea, paroxymal nocturnal dyspnea, Cheye-stokes respiration, cardiac asthma
PE
:lower limb edema, tachycardia, Cardiomegaly
Examination
:elevated BNP, ECG, cardiomegaly(CXR)
Rule-out
:不滿足Framingham criteria
gastrointestinal
腹壓增加(肥胖、懷孕)、壓力、生活習慣、下食道括約肌異常、胃排空障礙
esophageal reflux
Clinical presentation
:
burning(火燒心);飯後惡化,躺著惡化(睡眠問題),坐起緩解;服用制酸劑可緩解。
Examination
:
上消化道鋇劑攝影、24小時食道酸鹼值測定、胃鏡檢查。
下食道括約肌異常、食道阻塞
esophageal spasm
Clinical presentation
:
squeezing(需與心絞痛區別);吞嚥困難、吞嚥疼痛;服用NTG可緩解。
Examination
:
鋇劑食道攝影、食道括約肌測壓檢查。
劇烈嘔吐
esophageal rupture
Clinical presentation
: 呼吸困難、劇痛、休克、皮下氣腫。
Examination
: CXR(肋膜腔積水或氣體)、CT、內視鏡。
H. pylori、壓力、飲食生活習慣
peptic ulcer
Clinical presentation
: burning;飯後惡化、噁心、脹氣、血便。
Examination
: C-13吹氣檢驗、胃鏡。
高油飲食-結石-阻塞;非結石(ex 腫瘤)
gallbladder disease
Clinical presentation
:colicky, aching;飯後,右上腹,輻射至背、右肩,持續數小時;噁心、嘔吐、發燒。
Examination
: Murphy's sign, 黃疸、茶色尿、WBC↑, GOT,GPT↑, 腹部超音波、XR、CT、MRI、ERCP。
相關檢查
History
LQQOPERA
past medical history
PE
general
vital sign
pulmonary
cardiac
abdominal
musculoskeletal
ECG
CXR
Cardiac biomarkers
neuromuscular
injury, physical strain, arthritis, joint infection, tumor
costochondritis
Clinical presentation
:sternal, localized pain;休息或側臥時緩解,呼吸或躺下時加重。
Examination
: CXR, CT
disc breaks open or bulges out, putting pressure on the spinal cord or nerve roots
cervical disc disease
Clinical presentation
:localized pain, numbness
Examination
: XR, CT, PE (頭轉動可能造成手部麻木)
trauma, strain
Clinical presentation
:localized pain
Examination
: XR, CT, PE
HSV infection
herpes zoster
Clinical presentation
:sharp, burning, dermatomal pain, vesicular rash, 發燒等病毒性症狀。
Examination
: Tzanck smear, PCR, 免疫螢光染色、病毒培養。
vascular
主動脈media 遭破壞
acute aortic syndrome
(包括acute aortic dissection、penetrating ulcer、intramural hematoma)
Clinical presentation
:chest or upper back pain;tearing, sharp;sudden onset
PE
:脈膊不足、左右手收縮壓差異≧10 mmHg、低血壓≦90/60 mmHg
Examination
:CT
Rule out
:D-Dimer陰性(< 500 μg/L)2
肺部血管栓塞
pulmonary embolism
Clinical presentation
:sharp pain;sudden-onset dyspnea;下肢腫脹
Examination
:ECG(sinus tachycardia, T波 ST段改變 S1Q3T3);multiple slide CT、動脈血氧下降、D-dimer>500、肺動脈血管攝影
Rule-out
:D-Dimer陰性、PERC(Pulmonary Embolism Rule-out Criteria)
左心衰竭、PAH、肺部疾病、慢性血栓栓塞姓疾病等引起
pulmonary hypertension
Clinical presentation
: fatigue, 運動容易喘、周邊水腫、頸靜脈怒張
Examination
:右心導管檢查、CXR、ECG顯示右心肥大、ECHO
pulmonary
多因病毒感染、其他原因包括肺炎、肺結核、肺癌
pneumonia
Clinical presentation
: 咳嗽、痰、呼吸困難、發燒
PE
:dullness、發燒、血液檢查感染、CXR
肺泡pleura破裂-肋膜腔異常有空氣
pneumothorax分成open跟close,
嚴重可能導致tension pneumothorax
Clinical presentation
: 突然且尖銳的胸痛、呼吸困難
PE
:hyperresonnace
Examination
:CXR
psychological
emtional psychiatric condition
Clinical presentation
:variable chest discomfort (often tightness), dysnea, 在特定情況下被誘發出來。
History taking
: 精神科病史。
Ischemic Heart Disease
luminal stenosis<70%
mostly asympomatic
luminal stenosis>70%
Stable Angina
ACS
NSTEMI (transmural infarct)
STEMI(subendocardial infarct)
Unstable Angina
pathophysiology
type 1:acute coronary thrombosis、CAD
type 2:imbalance of myocardial oxygen supply ex: arrhythmias、anemia、coronary artery spasm
Risk factors
1.male 2.Age 3. smoking 4.DM 5.Hypertension 6.high LDL、TG、Chol 7.Family History
symptoms
L:retrosternal, radiation to submandible、shoulder、left arm
A:nausea、sweating、shortness of breath
Q:pressure、tightness、burning
Treatments
Baloon
Stent
Aspirin、Nitrates、Beta blockers、calcium channel blockers、choleterol lowering meds、ACE inhibitors、Ranolazine
coronary artery bypass
Enhanced external counterpulsation
case 1(下壁急性心肌梗塞):male、Chest discomfort (pressure on chest)、cold sweating、panic、DM、abnormal blood lipid level;Lab:CK 68 U/L(正常), CK-MB 3.5 ng/mL(正常), Troponin I 0.01 ng/mL(正常), D-dimer: 0.4 mg/L (正常)
Diagnosis
coronary angiopathy
cardiac biomarkers: only when infarct
ECG
Normal、inverted T wave or ST depression
NSTEMI
Hyperacute T waves or ST elevation、Q waves(old MI)、recciproccal changes
STEMI
Location: find out via leads
CT
GERD(Reflux esophagitis)
case 3(GERD):obese、1 cup of coffee per day、DM、hyperlipidemia with regulatory control、burning sensation when lying down、relieve when sit up
EKG is normal
Diagnosis
Upper endoscopy
Ambulatory acid probe test
Esophageal manometry
X-ray
Barium esophagram
PPI trial
Ultrasound
Symptom
Atypical Symptoms: Epigastric fullness, epigastric pressure, epigastric pain, dyspepsia, nausea, bloating, belching
Complications
hematemesis
esophageal ulceration
melena
stricture development
Barrett esophagus
Typical symptoms: Acid regurgitation, heartburn
Extraesophageal Symptoms: Chronic cough, bronchospasm, wheezing, hoarseness, sore throat, asthma, laryngitis, dental erosions
pathophysiology(食道括約肌張力降低或腹部壓力上升)
Risk factor
obesity
central nervous system depressants
increased gastric volume
pregnancy
hiatal hernia
delayed gastric emptying
alcohol and tobacco use
In many cases, no definitive cause is identified
Treatment
抑制胃酸分泌
H2 histamine receptor antagonists
Proton pump inhibitors
Surgery
acute aortic dissection
case 2(急性主動脈剝離): male、48yr、tall and thin、abnormal appearance、vital sign:37.2度C, 100bpm, 190/100 mmHg, 呼吸每分鐘18下、chest pain during exercising、chest and back tearing pain
Pathophysiology
definition
inner layer of the aorta tears, Blood surges through the tear, causing the inner and middle layers of the aorta to separate
Type A dissections:involve the ascending aorta and arch
type B dissections:involve the descending aorta
cause
hypertension
Marfan syndrome
trauma
diagnosis
Image
Transesophageal Echocardiogram視野清楚
chest X-ray:Widening of the aorta
MRI Scan: cross sectional scan of aorta
MRA:false lumen
CT:false lumen
Sudden tearing or ripping chest pain
Blood pressure difference between right and left arms
“swishing” sound of a murmur
sign & symptom
associated symptoms
acute pericarditis
acute pericardial tamponade (most common death of AD)
Precipitating factors
hypertension
Marfan syndrome
trauma
pregnancy
atherosclerosis
Quantity & Onset
sudden onset
Quality
Sudden severe pain, often described as a tearing, ripping or shearing sensation
Location
chest or upper back pain, sometimes radiates to the neck or down the back
疼痛會隨著姿勢改變