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thiazolidinediones Type_2_Nation_Thiazolidinediones_Actos_620px - Coggle…
thiazolidinediones
route of administration
take it orally
take it with or without eating
take it once a day
name
pioglitazone
rosiglitazone
indication
monotherapy in patients with severe renal failure
contraindications for insulin therapy
contraindications
liver failure
congestive heart failure
history of bladder cancer
active bladder cancer
macrohematuria of unknown origin
side effects
fluid retention
edema
weight gain
increased risk of heart failure
increased risk of bone fractures
storage conditions
do not store in the bathroom
store at room temperature
keep away from light and moisture
mechanism of action
increase storage of triglycerides
increase glucose utilization
decrease hepatic glucose production