Please enable JavaScript.
Coggle requires JavaScript to display documents.
What are the potential benefits for society of reseach using genetic…
What are the potential benefits for society of reseach using genetic technologies?
DNA Technonologies
DNA profiling / DNA fingerprinting
summary
identify + compare characteristic
scientific technique
developed
Sir Alec Jeffereys
benefits
analysing genetic relatinoships
conservation of species
identify individuals
unique combination of variable genome
unique DNA
types
gel electrophoresis
PCR
#
summary
amplify amount of DNA
genetic technology
benefits
makes available application
gel electrophoresis
DNA profiling
stages:
Denaturing
Annealing
Elongation
gel elctrophoresis
#
separate segments
based on length
rapid detection
sequence PCR fragments
valuable tool
carrier testing
individual and couples
analyse genetic relationships
family
forensic
evolutionary
DNA barcoding
summary
study gene
determine base sequence of entire genome
use DNA manipulation techniqies
isolate fragments of DNa
benefits
identifying species
closely relates species
morphologically similar
organisms distinguishable features removed
types
polymerase chain reaction (PCR)
restriction fragment length polymorphism (RFLP)
Mutations
cause
an alteration in genetic materia
effect
change DNA nucleotide sequence
cellular
individual
beneficial, harmful or neutral
populatons
genetic variation in population
heritable mutations
passed onto next generation
change in sequence
change specific functino of protein
Types
somatic mutations
germline mutations
DNA
amino acid
Biotechnology
DNA fingerprinting
application
uses
Gel Electrophoresis
application
uses
PCR
application
uses
Non-infectious Disease
genetic disease
cause
mutation of genes or chromosomes
abnormal gene
problems in cell division
mitosis or meiosis
Cystic Fibrosis
causes of CF
mutation
mutation of chromosome 7
cystic fibrosis conductor regulator (CFTR)
inherrted faulty gene from both parents
hereditary
CFTR gene is recessive
inherrited disease
severity of disease
treatment of disease
autosomal recessive disease
managment
what is cystic fibrosis?
genetic conditions
affect on the body
build-up of thick sticky mucus
Lungs and digestive system
lungs
mucus clogs airway
traps bacteria
infection
inflammation
respiratory failure
causing a wide range of challenging symptoms affecting the entire body
protein doesnt work
unable to move chloride
attract water to cell surface
mucus in organs, thick and sticky
Diagnosis and Genetics
inherit 2 copies of defective CF gene
one copy of defective CF gene
carriers
two CF carriers child chances inherritance
25 percent (1 in 4) the child will have CF
50 percent (1 in 2) the child will be a carrier but will not have CF
25 percent (1 in 4) the child will not be a carrier and will not have CF
statistics
affects 10,600 people in UK
1 in 25 are carriers
Symptoms
Very salty-tasting skin
Persistent coughing, at times with phlegm
Frequent lung infections including pneumonia or bronchitis
Wheezing or shortness of breath
Poor growth or weight gain in spite of a good appetite
Frequent greasy, bulky stools or difficulty with bowel movements
Male infertility
Use of Data Analysis
genetic testing
SNPs
quick and easy
Newborn screening program
impact on individual
early detection
improved treatment options
data
genetic occurence
benefits
provides data
large scale genomic analysis
diagnosis of disease
probability inherritance
future offspring
family background
pedigrees
Population Genetics Study