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Opioid Analgesics & Antagonists(PHARMACOLOGY) - Coggle Diagram

- - - - Fentanyl
      - hydromorphone
      - meperidine
      - morphine
      - methadone
      - oxymorphone
- - - - Clinical uses
        
        Moderate-to-severe pain dependence maintenance, reduces craving for alcohol (buprenorphine)
      - Pharmacokinetics
        
        Buprenorphine(long duration)Nalbuphine (parenteral only)
      - Mechanism of Action
        
        Partial µ agonist and
        κ antagonist
      - Toxicities
        
        Like strong agonists but can antagonize their
        effects
    - - Clinical uses
        
        -
      - Pharmacokinetics
        
        -
      - Mechanism of Action
        
        κ agonist and µ antagonist
      - Toxicities
        
        -
- - - - Antagonists
      - Naloxone
      - naltrexone
      - nalmefene
- - - - Reduce cough reflex toxic in overdose
    - - Duration: 0.5-1h
    - - Acute debilitating cough
    - - Mechanism uncertain Weak agonist inhibits norepinephrine and
        5-HT transporters
  - - - Weak agonist, blocks serotonin reuptake
    - - Moderate pain
        adjunctive to opioids in
        chronic pain states
    - - Duration: 4 - 6h
    - - Toxic in overdose
        (seizures)