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Spike-timing Dynamics of Neuronal Groups, Discussion, Materials and…
Spike-timing Dynamics of Neuronal Groups
Abstract
A neuronal network inspired by the anatomy of the cerebral cortex was simulated to study the self-organization of spiking neurons into neuronal groups.
The network consisted of 100 000 reentrantly interconnected neurons exhibiting known types of cortical firing patterns, receptor kinetics, short-term plasticity and long-term spike-timing-dependent plasticity (STDP), as well as a distribution of axonal conduction delays.
The dynamics of the network allowed us to study the fine temporal structure of emerging firing patterns with millisecond resolution.
We found that the interplay between STDP and conduction delays gave rise to the spontaneous formation of neuronal groups — sets of strongly connected neurons capable of firing time-locked, although not necessarily synchronous, spikes.
Despite the noise present in the model, such groups repeatedly generated patterns of activity with millisecond spike-timing precision
Exploration of the model allowed us to characterize various group properties, including spatial distribution, size, growth, rate of birth, lifespan, and persistence in the presence of synaptic turnover.
Localized coherent input resulted in shifts of receptive and projective fields in the model similar to those observed in vivo.
Discussion
Spike-timing-dependent Plasticity
Delays
Neuronal Groups
Self-organization
Competition
Reentry
Neuronal Groups and Synfire Chains
Statistics of Spike Rasters
Materials and Methods
Synaptic Dynamics
Input
Short-term Depression and Facilitation
Synaptic Conductances
Long-term Synaptic Plasticity
Spike-timing in Neuronal Groups
Anatomy
Spike Propagation Velocity
Neuronal Dynamics
Results
Spike-timing in Neuronal Groups
Identification and Characterization of Neuronal Groups
Growth
Lifespans
Persistence in the Presence of Synaptic Turnover
Collective Behavior
Rhythms and asynchronous firing
Synaptic Weights
Effects of Patterned Input
Conclusion
Introduction
References